Custom Peptides
Cayman Chemical 1-Oleoyl-2-hydroxy-sn-glycero-3-phosphocholine, Purity: ≥95%, CAS: 19420-56-5, 10 mg
A lysophospholipid; inhibits taurine uptake in Caco-2 cells at 200 µM; conditioned medium levels are increased in VEGF-stimulated primary NHBE cells, an effect that can be reversed by oleyloxyethyl phosphorylcholine; plasma levels are decreased in patients with lung cancer or abdominal aortic aneurysm
Cayman Chemical HLCL-61 (hydrochloride), Purity: ≥98%, CAS: 1158279-20-9, 10 mg
A PRMT5 inhibitor; inhibits the growth of multiple AML cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 μM, respectively); selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay; induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner; increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter
Cayman Chemical Atorvastatin lactone, Purity: ≥95%, CAS: 125995-03-1, 10 mg
An active metabolite of atorvastatin; inhibits HMG-CoA reductase (IC50 = 0.007 µM for the rat liver enzyme); inhibits CYP2C9.1, CYP2C9.3, and P-gp (IC50s = 16.8, 5.62, and 3.1-5.2 µM, respectively)
Cayman Chemical 2',5'-dideoxy Adenosine, Purity: ≥98%, CAS: 6698-26-6, 10 mg
A cell-permeable, P-site inhibitor of adenylate cyclase; inhibits forskolin-induced activation of a cAMP-dependent reporter gene in HEK293 cells with an IC50 value of 33 µM
Cayman Chemical 14-Deoxyandrographolide, Purity: ≥95%, CAS: 4176-97-0, 10 mg
A diterpene lactone with diverse biological properties; inhibits the growth of HL-60 cells (GI50 = 25.46 µM); cytotoxic to T47D cells (EC50 = 2.8 µg/ml); increases AMPK phosphorylation and glucose uptake in L6 myotubes and potentiates the effect of insulin to increase cell surface levels of GLUT4 in L6-GLUT4myc cells at 10 and 25 µM; reduces blood glucose levels in rats in a model of streptozotocin-induced diabetes and in db/db diabetic mice at 100 mg/kg; reduces ethanol-induced hepatotoxicity in rats at 15 mg/kg per day for the last four weeks of an eight-week ethanol exposure period; reduces protein carbonyl and TBARS levels and increases GSH levels in isolated rat hepatocytes in the same model
Cayman Chemical Imisopasem Manganese, Purity: ≥95%, CAS: 218791-21-0, 10 mg
A SOD mimetic; catalyzes dismutation of the superoxide anion with a catalytic rate constant of >2 x 107 M-1s-1; reduces carrageenan-induced paw edema and inhibits increases in paw exudate levels of TNF-α, IL-1β, and LDH in rats at 1-10 mg/kg, i.v. bolus; inhibits increases in lung and ileum MPO levels, indicating reduced neutrophil infiltration, and increases in plasma MDA, TNF-α, and IL-1β levels in a rat model of ischemia-reperfusion injury and shock induced by SAO at 0.1, 0.3, and 1 mg/kg
Cayman Chemical 16-Oxokahweol, Purity: ≥98%, CAS: 108664-99-9, 10 mg
A synthetic diterpene; increases cytosolic GST activity and acid-soluble sulfhydryl levels in mouse liver and small bowel mucosa at 10 µmol once per day for three days
Cayman Chemical Mahanimbine, Purity: ≥98%, CAS: 21104-28-9, 10 mg
A carbazole alkaloid; active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both); induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells at 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively); decreases body weight gain without affecting food intake and reduces increases in plasma total cholesterol and triglyceride levels in a rat model of high-fat diet-induced obesity at 30 mg/kg
Cayman Chemical Fenobam (hydrate), Purity: ≥98%, CAS: 63540-28-3, 10 mg
A noncompetitive antagonist and inverse agonist of mGluR5 that binds to an allosteric site; inhibits quisqualate-induced intracellular calcium mobilization in HEK293 cells expressing the human receptor (IC50 = 58 nM); inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM); reduces stress-induced hyperthermia in mice at 10 and 30 mg/kg; increases drinking time in the Vogel conflict test in rats at 30 mg/kg; induces analgesia in the formalin test in mice at 30 mg/kg
Cayman Chemical Bropirimine, Purity: ≥95%, CAS: 56741-95-8, 10 mg
An immunomodulator with diverse biological activities; a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs; dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week; reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg; delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE
Cayman Chemical Desethylchloroquine, Purity: ≥95%, CAS: 1476-52-4, 10 mg
An active metabolite of chloroquine; formed when chloroquine undergoes dealkylation, primarily by CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6; inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml)
Cayman Chemical Cirsiliol, Purity: ≥90%, CAS: 34334-69-5, 10 mg
A flavonoid with diverse biological activities; inhibits 5-LO and 12-LO (IC50s = 0.1 and 1 µM, respectively); inhibits release of SRS-A in passively sensitized isolated guinea pig lung (IC50 = 0.4 µM); induces relaxation of isolated precontracted rat uterus, urinary bladder, proximal aorta, and trachea; inhibits colony formation and migration of B16/F10 murine melanoma cells; enhances radiation-induced inhibition of tumor growth in an H1299 NSCLC mouse xenograft model at 200 µg/kg
Cayman Chemical Chrysosplenetin, Purity: ≥98%, CAS: 603-56-5, 10 mg
A flavonoid with diverse biological activities; active against P. falciparum in vitro (IC50 = 23 µM); inhibits the cytopathic effect of EV71 in Vero cells (EC50 = 0.68 µM); increases survival in a neonatal mouse model of EV71 infection at 1 and 5 mg/kg; increases proliferation and osteogenic differentiation of isolated BMSCs; prevents estrogen deficiency-induced bone loss in ovariectomized mice
Cayman Chemical Denudatine, Purity: ≥95%, CAS: 26166-37-0, 10 mg
An alkaloid with antiarrhythmic activities; prevents aconitine-induced arrhythmias in rats and increases survival in a rat model of calcium chloride-induced arrhythmias at 50 and 100 mg/kg
Cayman Chemical Isovitexin, Purity: ≥98%, CAS: 38953-85-4, 10 mg
A C-glycosylated flavone; scavenges DPPH radicals in a cell-free assay (IC50 = 370 µg/ml); cytotoxic to HepG2, MCF-7, and HCT116 cancer cells at 50 and 100 µg/ml; inhibits LPS-induced production of TNF-α and IL-6 and decreases iNOS and COX-2 levels in RAW 264.7 cells at 50 µg/ml; reduces cytotoxicity induced by Aβ (25-35) in PC12 cells at 200 µg/ml